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Background: |
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
EIF2AK2 (Phospho-Thr446) |
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Immunogen: |
Synthetic peptide of human EIF2AK2 (Phospho-Thr446) |
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Full name: |
eukaryotic translation initiation factor 2-alpha kinase 2 (Phospho-Thr446) |
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Synonyms： |
PKR; PRKR; EIF2AK1 |
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SwissProt: |
P19525 |
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IHC positive control: |
Human colon carcinoma |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
62 kDa |
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WB Positive control: |
K562 cells |
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WB Recommended dilution: |
500-1000 |
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IF Positive control: |
Hela cells |
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IF Recommended dilution |
100-200 |
