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021-54845833/15800441009
中文名称： 兔抗ECD多克隆抗体
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Background: |
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
ECD |
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Immunogen: |
Fusion protein of human ECD |
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Full name: |
ecdysoneless cell cycle regulator |
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Synonyms: |
GCR2; SGT1; HSGT1 |
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SwissProt: |
O95905 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human cervical cancer and Human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
73 kDa |
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WB Positive control: |
Jurkat and PC3 cell lysates |
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WB Recommended dilution: |
200-1000 |
