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021-54845833/15800441009
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Background: |
The Deltex family is responsible for influencing Notch signaling and may regulate transcription through interactions with specific transcription factors. Deltex proteins have a basic N-terminus, a central proline-rich region and a C-terminal RING-type zinc finger domain, a motif often found in ubiquitin-protein isopeptide ligases (E3). The RING-type zinc finger domain binds two Zn2+ atoms and forms a cross-brace motif that is essential for many proteins involved the ubiquitination pathway. DTX3L (Deltex-3-like), also known as BBAP, is a 740 amino acid protein that is similar to Deltex-3 and acts as a ubiquitin ligase in vitro. DTX3L can heterodimerize with Deltex-1, a transcriptional regulator, thereby enhancing the activity of the E3 ubiquitin ligase complex and increasing the influence of E3 on the Notch signaling pathway. |
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Applications: |
ELISA, WB |
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Name of antibody: |
DTX3L |
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Immunogen: |
Fusion protein of human DTX3L |
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Full name: |
deltex 3 like, E3 ubiquitin ligase |
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Synonyms: |
BBAP |
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SwissProt: |
Q8TDB6 |
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ELISA Recommended dilution: |
2000-5000 |
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WB Predicted band size: |
84 kDa |
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WB Positive control: |
A431 cell lysate |
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WB Recommended dilution: |
200-1000 |
