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中文名称：PPOX 抗原（重组蛋白）
英文名称： PPOX Antigen (Recombinant Protein)
别 名： protoporphyrinogen oxidase; VP; PPO; V290M
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 278-477 amino acids of human PPOX |
|
Full name: |
protoporphyrinogen oxidase |
|
Synonyms: |
VP; PPO; V290M |
|
Swissprot: |
P50336 |
|
Gene Accession: |
BC002357 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. |
