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中文名称：KLHL12 抗原（重组蛋白）
英文名称：KLHL12 Antigen (Recombinant Protein)
别 名： kelch like family member 12; DKIR; C3IP1
储 存： 冷冻（-20℃）
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Fusion protein corresponding to a region derived from 369-568 amino acids of human KLHL12 |
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Full name: |
kelch like family member 12 |
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Synonyms: |
DKIR; C3IP1 |
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Swissprot: |
Q53G59 |
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Gene Accession: |
BC003183 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. |
