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    ÖÐÎÄÃû³Æ£º ABCB7 ¿¹Ô­£¨ÖØ×éµ°°×£©

    Ó¢ÎÄÃû³Æ£º ABCB7 Antigen (Recombinant Protein)

    ±ð       Ãû£º ATP-binding cassette, sub-family B (MDR/TAP), member 7; ABC7; ASAT; Atm1p; EST140535

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    Fusion protein corresponding to a region derived from 501-753 amino acids of human ABCB7

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    Full name:

    ATP-binding cassette, sub-family B (MDR/TAP), member 7

    Synonyms:

    ABC7; ASAT; Atm1p; EST140535

    Swissprot:

    O75027

    Gene Accession:

    BC006323

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.


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