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中文名称：INHBA抗原（重组蛋白）
英文名称： INHBA Antigen (Recombinant Protein)
别 名： EDF; FRP
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
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Fusion protein corresponding to a region derived from 311-426 amino acids of human INHBA |
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Full name: |
inhibin, beta A |
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Synonyms: |
EDF; FRP |
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Swissprot: |
P08476 |
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Gene Accession: |
BC007858 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. |
