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021-54845833/15800441009
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Background: |
REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
DDIT4L |
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Immunogen: |
Fusion protein of human DDIT4L |
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Full name: |
DNA-damage-inducible transcript 4-like |
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Synonyms： |
REDD2; Rtp801L |
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SwissProt: |
Q96D03 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
