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021-54845833/15800441009
中文名称： CRK抗原（重组蛋白）
英文名称： CRK Antigen (Recombinant Protein)
别 名： p38; CRKII
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from C terminal 103 amino acids of human CRK |
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Full name: |
v-crk avian sarcoma virus CT10 oncogene homolog |
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Synonyms: |
p38; CRKII |
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Swissprot: |
P46108 |
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Gene Accession: |
BC009837 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
