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ÖÐÎÄÃû³Æ£º ZUP1 ¿¹Ô­£¨ÖØ×éµ°°×£©

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³Æ£º ZUP1 Antigen (Recombinant Protein)

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£º zinc finger containing ubiquitin peptidase 1; DUB; ZUFSP; C6orf113

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Fusion protein corresponding to a region derived from 379-578 amino acids of human ZUP1

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Full name:

zinc finger containing ubiquitin peptidase 1

Synonyms:

DUB; ZUFSP; C6orf113

Swissprot:

Q96AP4

Gene Accession:

BC016879

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a protein containing zinc finger motifs and a cysteine peptidase domain. The encoded protein functions as a K63-specific de-ubiquitinating enzyme that specifically cleaves long K63-linked polyubiquitin chains in the middle of a chain (i.e. "endo cleavage) rather than by removing the terminal ubiquitin from a chain. This enzyme is thought to be involved in the regulation of DNA repair by cleaving K63-linked ubiquitin chains at repair foci. This protein is related to proteases for the ubiquitin-like modifiers Ufm1 (ubiquitin fold modifier 1) and Atg8/Gabarapl2, but does not have any activity on these modifiers. [provided by RefSeq, Mar 2018]


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