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别 名： charged multivesicular body protein 2B; DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5
概 述
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Full name: |
charged multivesicular body protein 2B |
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Synonyms: |
DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5 |
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Swissprot: |
Q9UQN3 |
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Gene Accession: |
BC001553 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. |
