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021-54845833/15800441009
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Background: |
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CHMP2B |
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Immunogen: |
Fusion protein corresponding to a region derived from 94-213 amino acids of human CHMP2B |
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Full name: |
charged multivesicular body protein 2B |
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Synonyms: |
DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5 |
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SwissProt: |
Q9UQN3 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC Positive control: |
Human brain;Human esophagus cancer |
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IHC Recommended dilution: |
20-100 |
