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Fusion protein corresponding to a region derived from 322-455 amino acids of human HTR3A |
技术规格
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Full name: |
5-hydroxytryptamine receptor 3A |
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Synonyms: |
HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R |
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Swissprot: |
P46098 |
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Gene Accession: |
BC002354 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. |
