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021-54845833/15800441009
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Background: |
P23, also known as PTGES3 (prostaglandin E synthase 3) or TEBP (telomerase-binding protein p23), is a ubiquitously expressed protein that functions as a cochaperone and plays an important role in signal transduction. One of several proteins in the HSP 90-based molecular chaperone complex, P23 promotes the breakdown of transcriptional regulatory complexes by disrupting receptor-mediated transcriptional activation. P23 acts in a hormone-dependent manner to chaperone estrogen receptor alpha (ER ), a steroid complex, to its mature form and to regulate the expression of ER -related genes. Localized to the cytoplasm, P23 interacts with the glucocorticoid receptor (GR) and, through disassembly of the GR transcription machinery, is thought to inhibit GR-dependent transcription. The involvement of P23 in various steroid receptor-mediated pathways suggests close involvement in signal transduction and regulation of cellular processes. Upregulation of P23 is implicated in the invasion and metastasis of various cancers. |
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Applications: |
WB, IHC |
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Name of antibody: |
PTGES3 |
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Immunogen: |
Fusion protein of human PTGES3 |
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Full name: |
prostaglandin E synthase 3 (cytosolic) (PTGES3), transcript variant 1 |
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Synonyms: |
cPGES; P23; TEBP |
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SwissProt: |
Q15185 |
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IHC positive control: |
adenocarcinoma of human ovary tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
19 kDa |
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WB Positive control: |
A549 cell lysate |
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WB Recommended dilution: |
500-2000 |
