购物车
帮助
021-54845833/15800441009
中文名称： 兔抗ACVR2B多克隆抗体
|
Background: |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
ACVR2B |
|
Immunogen: |
Fusion protein of human ACVR2B |
|
Full name: |
activin A receptor, type IIB |
|
Synonyms： |
HTX4; ACTRIIB; ActR-IIB |
|
SwissProt: |
Q13705 |
|
ELISA Recommended dilution: |
1000-2000 |
|
IHC positive control: |
Human thyroid cancer and human cervical cancer |
|
IHC Recommend dilution: |
25-100 |
