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中文名称：兔抗CEP57多克隆抗体
英文名称： Anti-CEP57 rabbit polyclonal antibody
别 名： centrosomal protein 57; MVA2; PIG8; TSP57
相关类别： 一抗
储 存： 冷冻（-20℃）
抗 原： CEP57
宿 主： Rabbit
反应种属： Human, Mouse, Rat
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
CEP57 |
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Immunogen: |
Full length fusion protein |
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Full name: |
centrosomal protein 57 |
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Synonyms: |
MVA2; PIG8; TSP57 |
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SwissProt: |
Q86XR8 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human colorectal cancer and Human tonsil |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
57 kDa |
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WB Positive control: |
Hela cell lysate |
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WB Recommended dilution: |
500-2000 |
