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021-54845833/15800441009
中文名称：小鼠抗MAPK8单克隆抗体
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Background: |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. |
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Applications: |
WB, IF |
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Name of antibody: |
MAPK8 |
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Immunogen: |
Fusion protein of human MAPK8 |
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Full name: |
mitogen-activated protein kinase 8 |
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Synonyms: |
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2 |
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SwissProt: |
P45983 |
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WB Predicted band size: |
48 kDa |
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WB Positive control: |
C6 and 3T3 cell lysates |
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WB Recommended dilution: |
500-2000 |
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IF positive control: |
3T3 cells |
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IF Recommend dilution: |
50-100 |
