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中文名称：小鼠抗DTWD1单克隆抗体
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Background: |
DTWD1 (DTW domain-containing protein 1), also known as MDS009, is a 304 amino acid protein that contains one DXTW motif and belongs to the DTW family. Existing as three alternatively spliced isoforms, DTWD1 is encoded by a gene that maps to human chromosome 15q21.2. Chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. |
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Applications: |
WB, IHC |
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Name of antibody: |
DTWD1 |
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Immunogen: |
Fusion protein of human DTWD1 |
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Full name: |
DTW domain containing 1 |
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Synonyms: |
MDS009 |
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SwissProt: |
Q8N5C7 |
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IHC positive control: |
Human thyroid cancer |
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IHC Recommend dilution: |
200-500 |
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WB Predicted band size: |
35 KD |
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WB Positive control: |
U251 cell lysate |
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WB Recommended dilution: |
500-2000 |
