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中文名称： ZNF281 抗原（重组蛋白）
英文名称： ZNF281 Antigen (Recombinant Protein)
别 名： zinc finger protein 281; ZBP-99; ZNP-99
相关类别：抗原
储 存： 冷冻（-20℃）
概 述
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Full name: |
zinc finger protein 281 |
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Synonyms: |
ZBP-99; ZNP-99 |
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Swissprot: |
Q9Y2X9 |
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Gene Accession: |
BC060820 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF281, also known as GC-box-binding zinc finger protein 1, ZBP-99 or ZNP-99 (zinc finger DNA-binding protein 99), is a zinc finger protein that belongs to the Krüppel C2H2-type zinc finger protein family. It is expressed ubiquitously at low levels with predominant expression in kidney, liver, lymphocytes and placenta. ZNF281 localizes to the nucleus and contains four C2H2-type zinc fingers. ZNF281 plays a role in repressing the transcription of a variety of genes including Gastrin and ODC (ornithine decarboxylase). In particular, ZNF281 functions by binding to the G-rich box in the enhancer region of the gene. Upon DNA damage, ZNF281 may become phosphorylated by Atm or ATR. |
