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021-54845833/15800441009
中文名称：小鼠抗CDKN1A单克隆抗体
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Background: |
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]. |
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Applications: |
WB, IHC |
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Name of antibody: |
CDKN1A |
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Immunogen: |
Fusion protein of human CDKN1A |
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Full name: |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2 |
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Synonyms: |
CAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1 |
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SwissProt: |
P38936 |
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IHC positive control: |
carcinoma of human thyroid tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
18 kDa |
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WB Positive control: |
HepG2 and MDCK cell lysates |
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WB Recommended dilution: |
200-1000 |
