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别 名： anterior gradient 2, protein disulphide isomerase family member; AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116
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Background: |
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. |
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Applications: |
WB, IHC |
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Name of antibody: |
AGR2 |
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Immunogen: |
Fusion protein of human AGR2 |
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Full name: |
anterior gradient 2, protein disulphide isomerase family member |
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Synonyms: |
AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116 |
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SwissProt: |
O95994 |
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IHC positive control: |
Human prostate tissue and Human breast cancer |
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IHC Recommend dilution: |
500-2000 |
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WB Predicted band size: |
20 KD |
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WB Positive control: |
AGR2, AGR3 cell lysates |
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WB Recommended dilution: |
500-2000 |
