Name: TMEM256 抗原（重组蛋白）
Brand: 通蔚生物

中文名称： TMEM256 抗原（重组蛋白）

英文名称： TMEM256 Antigen (Recombinant Protein)

别名： transmembrane protein 256; C17orf61

储存：冷冻（-20℃）

相关类别：抗原

概述

Fusion protein corresponding to a region derived from 30-113 amino acids of human TMEM256

技术规格

Full name:	transmembrane protein 256
Synonyms:	C17orf61
Swissprot:	Q8N2U0
Gene Accession:	BC030270
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	TMEM256, also known as C17orf61, C17orf61 (chromosome 17 open reading frame 61) is a 113 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

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