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中文名称：HLA-DPB1 抗原（重组蛋白）
英文名称： HLA-DPB1 Antigen (Recombinant Protein)
别 名： major histocompatibility complex, class II, DP beta 1; DPB1; HLA-DP; HLA-DPB; HLA-DP1B
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 29-257 amino acids of human HLA-DPB1 |
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Full name: |
major histocompatibility complex, class II, DP beta 1 |
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Synonyms: |
DPB1; HLA-DP; HLA-DPB; HLA-DP1B |
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Swissprot: |
P04440 |
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Gene Accession: |
BC015000 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. |
