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021-54845833/15800441009
中文名称：TCF3 抗原（重组蛋白）
英文名称：TCF3 Antigen (Recombinant Protein)
别 名： transcription factor 3; E2A; E47; p75; AGM8; ITF1; VDIR; TCF-3; bHLHb21
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
技术规格
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Full name: |
transcription factor 3 |
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Synonyms: |
E2A; E47; p75; AGM8; ITF1; VDIR; TCF-3; bHLHb21 |
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Swissprot: |
P15923 |
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Gene Accession: |
BC110580 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. |
