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中文名称： RGS14 抗原（重组蛋白）
英文名称： RGS14 Antigen (Recombinant Protein)
别 名： regulator of G protein signaling 14
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
技术规格
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Full name: |
regulator of G protein signaling 14 |
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Swissprot: |
O43566 |
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Gene Accession: |
BC014094 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
