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021-54845833/15800441009
中文名称：兔抗CABLES2多克隆抗体
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Background: |
Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
CABLES2 |
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Immunogen: |
Synthetic peptide of human CABLES2 |
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Full name: |
Cdk5 and Abl enzyme substrate 2 |
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Synonyms： |
ik3-2; C20orf150; dJ908M14.2 |
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SwissProt: |
Q9BTV7 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human thyroid cancer and Human brain |
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IHC Recommend dilution: |
25-100 |
