购物车
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021-54845833/15800441009
中文名称：兔抗ARIH1多克隆抗体
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Background: |
ARIH1 (ariadne homolog), also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI (human homolog of Drosophila ariadne), MOP-6 (monocyte protein 6) or UBCH7BP (UBCH7 binding protein), is a 557 amino acid cytoplasmic protein. Expressed in a wide variety of tissues, ARIH1 contains two RING-type zinc fingers and one IBR (in-between RING fingers)-type domain. ARIH1 is believed to be involved in protein degradation and protein translation. ARIH1 interacts with UBCH7 and is thought to function as an E3 ubiquitin-protein ligase (or as a component of an E3 complex) that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme (UBCH7) and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, ARIH1 interacts with and polyubiquitylates eIF4E2, thereby targeting it for proteasomal degradation. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ARIH1 |
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Immunogen: |
Synthetic peptide of human ARIH1 |
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Full name: |
ariadne RBR E3 ubiquitin protein ligase 1 |
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Synonyms: |
ARI; HARI; HHARI; UBCH7BP |
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SwissProt: |
Q9Y4X5 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
50-100 |
