购物车
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021-54845833/15800441009
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Background: |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
TNFRSF1B |
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Immunogen: |
Fusion protein of human TNFRSF1B |
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Full name: |
Tumor necrosis factor receptor superfamily, member 1B |
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Synonyms： |
p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II |
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SwissProt: |
P20333 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human liver cancer and human cervical cancer |
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IHC Recommend dilution: |
5-20 |
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WB Predicted band size: |
48 kDa |
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WB Positive control: |
Human colon cancer |
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WB Recommended dilution: |
200-1000 |
