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Background: |
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. |
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Applications: |
WB |
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Name of antibody: |
SYNE3 |
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Immunogen: |
Synthesized peptide derived from internal of human C14orf49. |
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Full name: |
spectrin repeat containing, nuclear envelope family member 3 |
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Synonyms： |
NET53; Nesp3; C14orf49 |
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SwissProt: |
Q6ZMZ3 |
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WB Predicted band size: |
112 kDa |
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WB Positive control: |
Jurkat cells lysate |
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WB Recommended dilution: |
500-3000 |
