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021-54845833/15800441009
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Background: |
The membrane protein syntaxin 5 (STX5) is a key component of soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) complexes that regulate cellular protein transport, vesicle docking, and membrane fusion. Syntaxin 5 protein is found as a 42 kDa ("long") protein localized to the Golgi complex and endoplasmic reticulum, and a “short” 35 kDa isoform localized primarily to the Golgi. Formation of the syntaxin 5 SNARE complex, which also includes proteins Sec22B, Bet1, GOSR1, GOSR2, and Ykt6, allows for regulation of ER-to-Golgi transport, intra-Golgi transport, and endosome-to-Golgi retrograde transport. Research studies indicate that the syntaxin 5 SNARE complex also plays an essential role in autophagy following autophagosome formation. Intracellular protein transport mediated by the syntaxin 5 complex is required for transport and localized activity of lysosomal proteases. The experimental reduction or deletion of syntaxin 5 complex components results in non-functional lysosomes and accumulation of autophagosomes. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
STX5 |
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Immunogen: |
Fusion protein of human STX5 |
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Full name: |
syntaxin 5 |
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Synonyms: |
SED5; STX5A |
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SwissProt: |
Q13190 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
40 kDa |
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WB Positive control: |
HepG2, A431 and Raji cell lysates |
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WB Recommended dilution: |
500-2000 |
