ÖÐÎÄÃû³Æ£º Íÿ¹PLAU¶à¿Ë¡¿¹Ìå
Ó¢ÎÄÃû³Æ£º Anti-PLAU rabbit polyclonal antibody
±ð Ãû£º ATF; QPD; UPA; URK; u-PA; BDPLT5
¿¹ Ô£º PLAU
´¢ ´æ£º Àä¶³£¨-20¡æ£©
ËÞ Ö÷£º Rabbit
Ïà¹ØÀà±ð£º Ò»¿¹
·´Ó¦ÖÖÊô£º Human
±ê ¼Ç Î Unconjugate
¿Ë¡ÀàÐÍ£º rabbit polyclonal
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Background: |
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
PLAU |
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Immunogen: |
Fusion protein of human PLAU |
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Full name: |
plasminogen activator, urokinase |
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Synonyms£º |
ATF; QPD; UPA; URK; u-PA; BDPLT5 |
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SwissProt: |
P00749 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human gastric cancer and Human brain |
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IHC Recommend dilution: |
10-50 |

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