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021-54845833/15800441009
中文名称： 兔抗GSDMA多克隆抗体
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Background: |
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable). |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
GSDMA |
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Immunogen: |
Fusion protein of human GSDMA |
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Full name: |
gasdermin A |
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Synonyms: |
GSDM; FKSG9; GSDM1 |
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SwissProt: |
Q96QA5 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human colorectal cancer and Human ovarian cancer |
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IHC Recommend dilution: |
100-200 |
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WB Predicted band size: |
49 kDa |
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WB Positive control: |
LO2 and 293T cell lysates |
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WB Recommended dilution: |
500-2000 |
