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021-54845833/15800441009
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Background: |
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
GRIA4 |
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Immunogen: |
Synthetic peptide of human GRIA4 |
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Full name: |
glutamate ionotropic receptor AMPA type subunit 4 |
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Synonyms: |
GLUR4; GLURD; GluA4; GLUR4C |
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SwissProt: |
P48058 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human tonsil |
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IHC Recommend dilution: |
30-150 |
