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ÖÐÎÄÃû³Æ£º  Íÿ¹TRIB2¶à¿Ë¡¿¹Ìå


Ó¢ÎÄÃû³Æ£º  Anti-TRIB2 rabbit polyclonal antibody


±ð      Ãû£º C5FW; TRB2; GS3955


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ËÞ     Ö÷£º  Rabbit


¿¹     Ô­£º  TRIB2


·´Ó¦ÖÖÊô£º Human, Mouse


±ê ¼Ç Î  Unconjugate


¿Ë¡ÀàÐÍ£º rabbit polyclonal


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Background:

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

TRIB2

Immunogen:

Full length fusion protein

Full name:

tribbles pseudokinase 2

Synonyms£º

C5FW; TRB2; GS3955

SwissProt:

Q92519

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human gastric cancer

IHC Recommend dilution:

30-150






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