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Background: |
Fibrillarin is a 2'-O-methyltransferase located in fibrillar regions and Cajal bodies of the nucleolus, where RNA transcription and pre-RNA processing take place. Fibrillarin associates with several other structual proteins as well as box C/D snoRNA to form a complex that functions in pre-rRNA processing, pre-rRNA methylation and ribosome assembly. This complex catalyzes site-specific 2'-O-ribose methylation of targeted nucleotides within the rRNA sequence. The sequence, structure and function of fibrillarin are highly conserved and fibrillarin gene expression is essential for early embryonic development. |
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Applications: |
WB |
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Name of antibody: |
FBL |
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Immunogen: |
Fusion protein of human FBL |
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Full name: |
fibrillarin |
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Synonyms： |
FBL; FIB; FLRN; RNU3IP1 |
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SwissProt: |
P22087 |
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WB Predicted band size: |
34 kDa |
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WB Positive control: |
Hela, A375, U20S, COS1, COS7 and PC12 cells, brain and testis tissue |
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WB Recommended dilution: |
500-2000 |
