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英文名称： VHL Antigen (Recombinant Protein)
别 名： RCA1; VHL1; pVHL; HRCA1
相关类别： 抗原
概 述
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Full name: |
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
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Synonyms: |
RCA1; VHL1; pVHL; HRCA1 |
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Swissprot: |
P40337 |
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Gene Accession: |
BC058831 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
