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021-54845833/15800441009
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Background: |
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
ELAC2 |
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Immunogen: |
Fusion protein of human ELAC2 |
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Full name: |
elaC ribonuclease Z 2 |
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Synonyms: |
ELC2; HPC2; COXPD17 |
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SwissProt: |
Q9BQ52 |
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IHC positive control: |
Human gastric cancer and human liver cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
92 kDa |
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WB Positive control: |
LoVo and Hela cells |
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WB Recommended dilution: |
200-1000 |
