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021-54845833/15800441009
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Background: |
EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking. The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes. The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin. Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion. |
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Applications: |
ELISA, WB |
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Name of antibody: |
EEA1 |
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Immunogen: |
Synthetic peptide of human EEA1 |
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Full name: |
early endosome antigen 1 |
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Synonyms: |
MST105; ZFYVE2; MSTP105 |
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SwissProt: |
Q15075 |
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ELISA Recommended dilution: |
5000-10000 |
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WB Predicted band size: |
163 kDa |
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WB Positive control: |
Hela, 293T, RAW264.7 and NIH/3T3 cell lysates |
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WB Recommended dilution: |
200-1000 |
