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021-54845833/15800441009
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Background: |
This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
SPTLC1 |
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Immunogen: |
Fusion protein of human SPTLC1 |
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Full name: |
serine palmitoyltransferase, long chain base subunit 1 |
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Synonyms： |
HSN1; LBC1; LCB1; SPT1; SPTI; HSAN1 |
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SwissProt: |
O15269 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
53 kDa |
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WB Positive control: |
Lovo cells |
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WB Recommended dilution: |
200-1000 |
