购物车
帮助
021-54845833/15800441009
中文名称：兔抗TYROBP多克隆抗体
技术规格
|
Background: |
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
TYROBP |
|
Immunogen: |
Full length fusion protein |
|
Full name: |
TYRO protein tyrosine kinase binding protein |
|
Synonyms： |
DAP12; KARAP; PLOSL |
|
SwissProt: |
O43914 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human brain |
|
IHC Recommend dilution: |
25-100 |
