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中文名称：DHFR抗原（重组蛋白）
英文名称： DHFR Antigen (Recombinant Protein)
别 名： DYR; DHFRP1
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 2-187 amino acids of human DHFR |
|
Full name: |
dihydrofolate reductase |
|
Synonyms: |
DYR; DHFRP1 |
|
Swissprot: |
P00374 |
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Gene Accession: |
BC000192 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. |
