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中文名称： 兔抗MED12多克隆抗体
英文名称： Anti-MED12 rabbit polyclonal antibody
别 名： OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230
相关类别： 一抗
储 存： 冷冻（-20℃）
宿 主： Rabbit
抗 原： MED12
反应种属： Human, Mouse
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
MED12 |
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Immunogen: |
Synthetic peptide of human MED12 |
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Full name: |
mediator complex subunit 12 |
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Synonyms： |
OKS; FGS1; HOPA; OPA1; OHDOX; ARC240; CAGH45; MED12S; TNRC11; TRAP230 |
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SwissProt: |
Q93074 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human breast cancer |
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IHC Recommend dilution: |
25-100 |
