购物车
帮助
021-54845833/15800441009
中文名称： IKBIP 抗原（重组蛋白）
英文名称： IKBIP Antigen (Recombinant Protein)
别 名： IKBKB interacting protein; IKIP
储 存： 冷冻（-20℃）
相关类别： 抗原
概述
|
Fusion protein corresponding to a region derived from 71-350 amino acids of human IKBIP |
|
Full name: |
IKBKB interacting protein |
|
Synonyms: |
IKIP |
|
Swissprot: |
Q70UQ0 |
|
Gene Accession: |
BC058933 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
IKIP (Inhibitor of nuclear factor kappa-B kinase-interacting protein, IKK-interacting protein) is a single-pass membrane protein that shares a common promoter with APAF1. APAF1 and IKIP are both induced by X irradiation, however, the two gene products are transcribed in different directions. The IKIP gene is believed to be a target for p53 as expression of IKIP has been shown to promote apoptosis. IKIP has four known isoforms, three of which are found traversing the endoplasmic reticulum membrane. IKIP isoform 4 has a deletion of the transmembrane region which leads to a homogenous distribution of the protein within the cell. The IKIP gene products are expressed in vascular endothelial cells, while the isoform 4 has also been detected in lung, kidney, spleen, thymus and skeletal muscle. |
