购物车
帮助
021-54845833/15800441009
|
Fusion protein corresponding to a region derived from 190-627 amino acids of human PTPN22 |
|
Full name: |
protein tyrosine phosphatase, non-receptor type 22 (lymphoid) |
|
Synonyms: |
LYP; PEP; LYP1; LYP2; PTPN8 |
|
Swissprot: |
Q9Y2R2 |
|
Gene Accession: |
BC017785 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
