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Fusion protein corresponding to a region derived from 260-509 amino acids of human PRAME |
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Full name: |
preferentially expressed antigen in melanoma |
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Synonyms: |
MAPE; OIP4; CT130; OIP-4 |
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Swissprot: |
P78395 |
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Gene Accession: |
BC014074 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. |
