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中文名称：ICAM1抗原（重组蛋白）
英文名称： ICAM1 Antigen (Recombinant Protein)
别 名： BB2; CD54; P3.58
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 28-328 amino acids of human ICAM1 |
|
Full name: |
intercellular adhesion molecule 1 |
|
Synonyms: |
BB2; CD54; P3.58 |
|
Swissprot: |
P05362 |
|
Gene Accession: |
BC015969 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. |
