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021-54845833/15800441009
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Full name: |
X-ray repair complementing defective repair in Chinese hamster cells 6 |
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Synonyms: |
ML8, KU70, TLAA, CTC75, CTCBF, G22P1 |
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Swissprot: |
P12956 |
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Gene Accession: |
BC008343 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. |
