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    ÖÐÎÄÃû³Æ£º  DLD¿¹Ô­£¨ÖØ×éµ°°×£©

    Ó¢ÎÄÃû³Æ£º DLD Antigen (Recombinant Protein)

    ±ð      Ãû£º E3; LAD; DLDD; DLDH; GCSL; PHE3

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    Fusion protein corresponding to C terminal 250 amino acids of human DLD


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    Full name:

    dihydrolipoamide dehydrogenase

    Synonyms:

    E3; LAD; DLDD; DLDH; GCSL; PHE3

    Swissprot:

    P09622

    Gene Accession:

    BC018696

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants.


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