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021-54845833/15800441009
中文名称： CCDC106抗原（重组蛋白）
英文名称： CCDC106 Antigen (Recombinant Protein)
别 名： ZNF581; HSU79303
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from N terminal 243 amino acids of human CCDC106 |
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Full name: |
coiled-coil domain containing 106 |
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Synonyms: |
ZNF581; HSU79303 |
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Swissprot: |
Q9BWC9 |
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Gene Accession: |
BC000412 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53. |
