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抗 原： PDGFRA
Background:
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].
Applications:
WB, IHC
Name of antibody:
PDGFRA
Immunogen:
Fusion protein of human PDGFRA
Full name:
platelet-derived growth factor receptor, alpha polypeptide (PDGFRA)
Synonyms:
CD140A; PDGFR-2; PDGFR2; RHEPDGFRA
SwissProt:
P16234
IHC positive control:
human colon tissue and adenocarcinoma of human colon tissue; human Ovary tissue
IHC Recommend dilution:
30-150
WB Predicted band size:
123 kDa
WB Positive control:
NIH/3T3 cell lysate
WB Recommended dilution:
500-2000
